THE UNIVERSITY OF MISSISSIPPI | 662-915-7283 | outreach@olemiss.edu | Home | Staff | Ole Miss | Regionals
FIND IT QUICK!  A B C D E F G H I J K L M N O P Q R S T U V W XYZ
UM Pharmacy logo
AAPS logo
group shot of tablet course students in front of Pharmacy building

student in lab

Course Description

This course is intended to provide an overview of the fundamental concepts of the technology for preparation of uncoated/coated tablet products including hot melt extrudates. Participants will work in teams to prepare uncoated/coated tablet dosage forms including hot melt extrudates and conduct selected relevant testing for evaluation and quality control.

Lectures will include topics in the tableting processes and hot melt extrusion, such as preformulation, extrusion, granulation, tableting, and coating, as well as stability, validation, product evaluation, FDA regulatory requirements, and SUPAC guidelines.

Laboratory will consist of "20 hours of hands-on training" and include preformulation, hot-melt extrusion, granulation, tableting, coating, and tablet evaluation.

Course Dates

  • March 15-20, 2015
  • May 31-June 5, 2015
  • September 13-18, 2015

Course Objectives

Through laboratory practice and lectures, the course is designed to allow participants to:
  • Develop an overall understanding of the science and technology of solid dosage form processing with the introduction of hot melt extrusion to the course
  • Explore concepts of scale up, process validation, product evaluation, and FDA regulatory requirements
  • Learn or review principles in the technologies of development, production, and quality control including QbD and PAT
  • Gain hands-on experience in planning, processing, and testing uncoated/coated tablets including hot melt extrudates
  • Work and exchange ideas with faculty and other participants

Who Should Attend

This course presents an in-depth study of tablet processing including an extensive laboratory program, which now includes hot melt extrusion. It emphasizes the industrial application of the development, processing, and quality control functions. It is suitable to introduce this course to technical personnel from research, development, production, and quality control, as well as administrators, FDA investigators, or other individuals such as educators who need an introduction to tableting.

View Past Class Photos

Course Outline

Registration, reception and orientation will be 6:00-7:30 pm on Sunday. The course will end at 12:00 pm Friday.

Lecture topics covered in the course Include:
  • Preformulation Techniques
  • Formulation Selection
  • Excipient Uses and Case Studies
  • Mixing and Blending
  • Granulation and Drying Principles
  • Powder Compression and Compaction
  • Scale Up Considerations for Granules and Tablets
  • Physical Evaluation of Tablets
  • Introduction to Coating and Sugar Coating
  • Film Coating
  • Tablet Development Overview
  • Hot Melt Extrusion
  • Bioavailability/Bioequivalence
  • IVIVC
  • Supac Guidelines
  • Stability/Expiration Dating – FDA Requirements

Laboratory Content

LAB 1 (Preformulation)
  • Particle Surface Area and Porosity Analysis
  • Particle Size and Shape Analysis
  • Density Analysis
  • Moisture Adsorption/Desorption Isotherms
  • Texture Analysis
  • Thermogravimetric Analysis
  • Differential Scanning Calorimetry
AAPS logo
LAB 2 (Granulation, Extrusion/Spheronization)
  • High Shear Mixing and Wet Granulation
  • Hot-Melt Granulation
  • Extrusion – Spheronization
  • Fluid-Bed Drying
LAB 3 (Tabletting)
  • Excipient Compressibility/Loading CapacityEvaluation
  • Tablet Compression with Piccola Press
  • Generation of Hardness – Compression Profiles
LAB 4 (Hot Melt Extrusion, Quality Control
  • Hot-Melt Extrusion
  • Tablet Evaluation (Dissolution, Disintegration, Friability)
LAB 5 (Coating, Granulating)
  • Fluid-Bed Granulation
  • Particle and Tablet Coating Using Fluid-Bed
  • Tablet Coating Using a Pan Coater
laboratory

Laboratory Facilities

Participants will have the opportunity to use state-of-the-art equipment including:
  • Perkin Elmer DSC, TGA
  • Texture Technologies TA.XT
  • Micromeritics Surface Area Analyzer, Particle Size Analyzer, Density Analyzer, Particle Insight
  • Surface Measurement Systems DVS Intrinsic Moisture Sorption Analyzer
  • LCI Extrusion-Spheronizer
  • Vector High Shear Mixer
  • Mendel Fluid Bed Processor
  • Piccola Bench-Top Instrumented Rotary Press
  • Glatt Fluid Bed Dryer/Coater
  • Vector Tablet Pan Coater
  • pION Rainbow Dynamic Dissolution Monitor System
  • Hanson SR8 Dissolution Test Station
  • Thermo Scientific Genesys TM 6 UV Spectrophotometer
  • Thermo Hot-Melt Extruder
  • Sotax Disintegration Tester, Friability Tester, Hardness Tester

Fee and Enrollment

The course fee is $3,000 and includes tuition, lab coats, laboratory supplies, daily refreshments, lunch, and a reception. Pre-registration for the course is highly recommended. Mail or fax the completed form to the Course Registrar.

Registration cancelled more than 30 days before the start of the course will be subject to a cancellation fee of $1,000, and the balance will be refunded. There will be no refund of fees if registration is cancelled 30 days or less before the start of the course. Substitution of another person from your company will be accepted.

To provide an informal atmosphere and allow for individualized instruction, enrollment is limited. Registrations received after the maximum enrollment is reached will be offered priority in the next scheduled course or the entire enrollment fee will be returned.

REGISTER ONLINE

Location

The course will be held on the campus of the University of Mississippi, which is located one mile from downtown Oxford, Mississippi, and approximately 75 miles south of Memphis, Tennessee. Participants should use the Memphis International Airport for air travel. Lectures will be held in the E.F. Yerby Conference Center and the laboratory program will be held in nearby Faser Hall on the University of Mississippi campus.

laboratory

Accommodations

A block of rooms with special group rates has been reserved at Inn at Ole Miss Hotel. The Inn at Ole Miss Hotel is located on campus at 120 Alumni Drive. Participants may contact the hotel by phone at (662) 234-2331 or (888) 486-7666 or by fax at (662) 236-4835. Participants are responsible for making their own hotel reservations. Participants should ask for the Tablet Technology for Pharmacy Professionals Group room block when registering.Reservations by attendees must be confirmed two weeks prior to the course to receive the special room block rates. Three room sizes are available.

Special Accommodations

Please call Barbara Thompson, Course Coordinator and Registrar at (662) 915-5811 or email her at bthompso@olemiss.edu, if you need special accommodations such as dietary, sight, hearing, or access at this course.

Transportation

Persons who plan to fly to the course should book their flights to and from Memphis (Tennessee) International Airport. The University will provide a shuttle service for course participants who arrive at the Memphis International Airport (approximately 75 miles or 1 hour and 15 minutes drive). The cost of the shuttle is $135 round trip or $85 one-way. Shuttle reservations must be made and paid for in advance of travel by check (made payable to the University of Mississippi) or by Visa or MasterCard. If you would like to use the shuttle service, please contact Drew Pruitt, Project Administrator at 662-915-5132 or email: appruitt@olemiss.edu. Shuttles will be confirmed via e-mail. Please meet your shuttle driver inside the airport and nearby Baggage Claim, Area B escalator. (AMTRAK shuttle cost is $135 round trip or $85 one-way.)

Pharmaceutical Research, Development and Training Laboratories: Tablet Technology

Course Directors

Faculty
  • Dr. S. N. Murthy
  • Dr. Walter Chambliss
  • Dr. Nigel Langley
  • Mr. Mike Yelvigi
Graduate Students/Post-Doctoral Scientists
  • Hemlata Patil
  • Joe Morott
  • Naresh Modepalli
  • Nagendra S. Punyamurthula
  • Xin Feng
  • Manjeet Pimparade
  • Dr. Wenli Lu
  • Dr. Jum Bon Park
External Course Faculty
  • Mr. John F. Addison, Consultant
  • Mr. Brad Beissner, Ashland
  • Dr. Brian Carlin, FMC
  • Mr. Edward Godek, Glatt Air
  • Mr. Samer Habash, LCI
  • Dr. Kerry Johanson, Material Flow Solutions, Inc.
  • Mr. Randy Koch, Texture Technologies
  • Mr. Gus LaBella, Colorcon Corp.
  • Mr. Ronald Levans, Merck Consumer Care
  • Dr. Robert Marion, Ally Consulting, LLC
  • Mr. Darvin Martin, Sotax
  • Mr. Scott Martin, Thermo-Fisher
  • Dr. William McLaughlin, Merck Consumer Care
  • Dr. Tom McNabb, Merck Consumer Care
  • Mr. Benjamin Murugesu, Quadro Engineering
  • Dr. Carmen Popescu, Roquette, Inc.
  • Dr. Stuart Porter, Ashland
  • Dr. Chris Rainey, Consultant
  • Mr. Christopher Rodriguez, Thermo-Fisher
  • Mr. Jeff Schiavoni, Sotax
  • Mr. Robert Sedlock, SMI
  • Mr. Nick Slater, Freund-Vector
  • Mr. Timothy Smith, Freund-Vector
  • Dr. Art Straughn, Consultant
  • Ms. Lana Terzian, Ashland
  • Dr. Gerard Thone, FMC
  • Mr. De Wood, Micromeritics, Inc.
  • Ms. Lauren Wood, LCI

Tablet Technology: Acknowledgements

The faculty and staff of the Department of Pharmaceutics and the Pii Center for Pharmaceutical Technology in the Department of Pharmaceutics, School of Pharmacy at The University of Mississippi, Oxford, gratefully acknowledge the following corporations for their sponsorship, gracious donation of equipment and supplies, and providing instructors for this comprehensive course.

  • Ashland Aqualon, Wilmington, DE
  • BASF Pharma Ingredients and Services, Tarrytown, NY
  • Chris Hansen, Inc., Mahwah, NJ
  • Colorcon, West Point, PA
  • Distek Inc., North Brunswick, NJ
  • Dow Chemical U.S.A., Midland, MI
  • Evonik, Inc., Piscataway, NJ
  • Fitzpatrick Corporation, Elmhurst, IL
  • FMC Corporation, Princeton, NJ
  • Foremost USA, Baraboo, WI
  • Gattefossé USA, Paramus, NJ
  • Glatt Air Techniques, Inc., Ramsey, NJ
  • Hanson Research Corporation, Chatsworth, CA
  • Hercules Inc., Wilmington, DE
  • LCI Corporation, Charlotte, NC
  • Mallinkrodt Specialty Chemicals Corporation, West Orange, NJ
  • Merck Consumer Care, Memphis, TN
  • Mettler Instrument Corporation., Hightstown, NJ
  • Micromeritics, Norcross, GA
  • Moreflex, Inc., Greensboro, NC
  • Mutchler, Inc., Harrington Park, N
  • pION, Woburn, MA
  • Quest International, Hoffman Estates, IL
  • Robot-Coupe USA, Inc., Jackson, MS
  • Sartorius Corporation, Edgewood, NY
  • SMI, Specialty Measurements Inc., Lebanon, NJ
  • Sotax, Hopkinton, MA
  • SPI Polyols, Inc., Wilmington, DE
  • Surface Measurement Systems, Allentown, PA
  • Vector Corporation, Marion, IA